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TGP Faculty

Judith Agudo

Judith Agudo

Assistant Professor of Immunology, Harvard Medical School

Department

Immunology

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Immunogenicity of stem cells

Dan Barouch

Dan Barouch

William Bosworth Castle Professor of Medicine, Harvard Medical School
Director, Center for Virology and Vaccine Research, BIDMC

Department

Virology

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Immunology and pathogenesis of viral infections and developing novel vaccine and treatment strategies.

Tom Bernhardt

Tom Bernhardt

Professor of Microbiology and Immunobiology, Harvard Medical School
Associate Director of Biological and Biomedical Sciences, Harvard Medical School

Department

Microbiology

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Molecular mechanisms of bacterial growth

Rameen Beroukhim

Rameen Beroukhim

Associate Professor of Medicine

Department

Cancer Biology

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Investigations of the genetic changes that occur through cancer evolution and their affect on cancer behavior.

Stephen Blacklow

Stephen Blacklow

Gustavus Adolphus Pfeiffer Professor, Department of Biological Chemistry and Molecular Pharmacology (BCMP)
Chair of Department of BCMP, Harvard Medical School
Member of Department of Cancer Biology, Dana-Farber Cancer Institute

Department

BCMP

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Understand molecular mechanisms of signal transduction in normal and pathophysiologic contexts

Sara Buhrlage

Sara Buhrlage

Assistant Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Assistant Professor of Cancer Biology, Dana-Farber Cancer Institute

Department

BCMP

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Revolutionizing our ability to interrogate deubiquitinase (DUB) biology, validate DUBs as therapeutic targets, and develop small molecule-based ligands suitable for clinical development

Barbara Burleigh

Barbara Burleigh

Professor of Immunology and Infectious Diseases

Department

Immunology

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Studying of host fatty acid metabolism and its role in fueling T. cruzi replication in myoblasts and iPSC-derived human cardiomyocytes

Flaminia Catterucia

Flaminia Catterucia

Professor at the Department of Immunology and Infectious Diseases in the Harvard T.H. Chan School of Public Health

Department

Immunology

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Molecular basis of reproductive biology in Anopheles mosquitoes

Constance Cepko

Constance Cepko

Bullard Professor of Genetics and Neuroscience at Harvard Medical School
Professor of Ophthalmology at Mass. Eye and Ear Infirmary

Department

Genetics

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The mechanisms that cells use when they choose their fate during development of the central nervous system

Edward Chouchani

Edward Chouchani

Associate Professor of Cancer Biology (Dana-Farber Cancer Institute)
Associate Professor of Cell Biology (HMS)

Department

Cell Bio

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We apply mass spectrometry and biochemical approaches to understand how metabolites regulate cellular function in pre-clinical models of health and disease

George Church

George Church

Robert Winthrop Professor of Genetics, Harvard Medical School

Department

Genetics

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Transformative technologies for reading & writing 3D/4D structures at any scale

Karen Cichowski

Karen Cichowski

Professor of Medicine, Harvard Medical School
Professor of Medicine/Genetics, Brigham And Women's Hospital

Department

Genetics

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How deregulated cell signaling drives cancer

Monica Colaiacovo

Monica Colaiacovo

Professor of Genetics

Department

BCMP

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Mechanisms underlying germline maintenance and accurate chromosome inheritance during meiosis

Phil Cole

Phil Cole

Professor of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Department

Genetics

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The chemical biology of protein post-translational modifications (PTMs) in the context of signaling, epigenetics, and cancer

Sloan Devlin

Sloan Devlin

Assistant Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Associate Member of the Harvard Digestive Disease Center

Department

BCMP

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Leveraging expertise in organic chemistry, analytical chemistry, biochemistry, microbiology, cell biology, and gnotobiotic in vivo experiments to understand how human gut bacteria contribute to health and disease

Manoj Duraisingh

Manoj Duraisingh

John LaPorte Given Professor of Immunology and Infectious Diseases

Department

Immunology

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The elucidation of the mechanism by which Plasmodium parasites invade host red blood cells (RBCs), within which they proliferate or become transmissible sexual forms

Michael Eck

Michael Eck

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Professor of Cancer Biology, Dana-Farber Cancer Institute

Department

BCMP

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Using biochemical and biophysical methods (including X-ray crystallography and cryo electron microscopy) to distill problems of central importance in cancer biology to their structural and mechanistic essentials.

Eric Fischer

Eric Fischer

Assistant Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Independent Investigator of Cancer Biology, Dana-Farber Cancer Institute

Department

BCMP

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Combining structural biology, cell biology and chemical biology to address the molecular workings of these multi-component ubiquitin ligases.

Benjamin Gewurz

Benjamin Gewurz

Associate Professor, Medicine, Harvard Medical School
Physician, Medicine/Infectious Disease, Brigham And Women's Hospital
Associate Chair, Virology Program, Harvard Medical School

Department

Medicine

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The gamma-herpesvirus Epstein Barr virus (EBV) as a master regulator of B-cell biology

David Golan

David Golan

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
George R. Minot Professor of Medicine, Brigham and Women's Hospital
Dean for Research Operations and Global Programs, Research Operations and Global Programs, Harvard Medical School

Department

BCMP

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Smita Gopinath

Smita Gopinath

Assistant Professor of Immunology and Infectious Diseases
Immunology and Infectious Diseases

Department

Immunology

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The interactions between the commensal microbiota, pathogens and the host immune response in the one place they must necessarily meet – the mucosa

Chenghua Gu

Chenghua Gu

Professor of Neurobiology, Harvard Medical School

Department

Neurobiology

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The cellular and physiological mechanisms underlying the unique neurovascular interactions including the blood-brain barrier and neurovascular coupling, and to harness our discoveries for therapeutics

James Gusella

James Gusella

Bullard Professor of Neurogenetics, Genetics, Harvard Medical School
Director, Center for Human Genetic Research, Massachusetts General Hospital

Department

Genetics

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Genetics of disease from gene discovery through pathogenesis, prediction and treatment

Stephen Haggarty

Stephen Haggarty

Associate Professor of Neurology, Harvard Medical School
Associate in Neuroscience, Massachusetts General Hospital
Director of Chemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital

Department

Chem Bio

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The cellular mechanisms underlying neuroplasticity and related pathways for the treatment of various neuropsychiatric and neurological disorders

Darren Higgins

Darren Higgins

Professor of Microbiology, Harvard Medical School

Department

Microbiology

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The molecular mechanisms of intracellular bacterial pathogenesis, host-pathogen interactions and the cellular immune response to intracellular pathogens

Cigall Kadoch

Cigall Kadoch

Assistant Professor of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School
Institute Member and Co-Director, Epigenomics Program, Broad Institute of Harvard and MI

Department

BCMP

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Chromatin Remodeling in Health and Disease

Randall King

Randall King

Harry C. McKenzie Professor of Cell Biology, Harvard Medical School

Department

Cell Bio

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Understanding the Role of the Ubiquitin System During Cell Division

Andrew Kruse

Andrew Kruse

Professor of Biological Chemistry and Molecular Pharmacology

Department

BCMP

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The molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and molecular pharmacology

Dan Kuritzkes

Dan Kuritzkes

Harriet Ryan Albee Professor of Medicine

Department

Medicine

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Antiretroviral therapy and drug resistance in HIV-1 infection

David Liu

David Liu

Thomas Dudley Cabot Professor of the Natural Sciences
Howard Hughes Medical Institute Investigator

Department

CCB

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Creatively integrating chemistry and evolution to illuminate biology and enable new therapeutics

Jeffrey Macklis

Jeffrey Macklis

Max and Anne Wien Professor of Life Sciences
Professor of Stem Cell and Regenerative Biology, Harvard University
Professor of Neurology, Harvard Medical School
Director, Developmental and Regenerative Biology Ph.D. Program, Harvard University
Faculty Member, Harvard University Center for Brain Science
Executive Committee Member, Harvard Stem Cell Institute

Department

SCRB

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Neocortical projection neuron development and subtype specification in mice and human neuron models

Brendan Manning

Brendan Manning

Acting Chair and Professor of Molecular Metabolism, Department of Molecular Metabolism, Harvard. T.H. Chan School of Public Health
Affiliate Professor of Cell Biology, Harvard Medical School
Member of the Dana Farber/Harvard Cancer Cente

Department

Cell Bio

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Cell signaling and metabolism in cancer, metabolic diseases, and aging

Debbie Marks

Debbie Marks

Associate Professor of Systems Biology

Department

Sys Bio

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Building models to make sense of genetic variation and design biological tools for environmental and human health.

Jarrod Marto

Jarrod Marto

Associate Professor, Pathology, Harvard Medical School
Associate Professor, Cancer Biology, Oncologic Pathology, Dana-Farber Cancer Institute

Department

Pathology

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Interrogating the functional proteome to understand how genomic alterations, environmental insults, or the action of small molecule chemical probes impact individual proteins

Marcela Maus

Marcela Maus

Associate Professor, Medicine, Harvard Medical School
Director of Cellular Immunotherapy, Cancer Center, Massachusetts General Hospita

Department

Medicine

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Designing and Evaluating next generation genetically-modified (CAR) T cells as immunotherapy in patients with cancer

Ralph Mazitschek

Ralph Mazitschek

Assistant Professor at Harvard Medical School and Co-Director of the Chemical Biology Platform at the Center for Systems Biology at Massachusetts General Hospital (MGH)

Department

CSB

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The interface of biology and organic chemistry, and aims to study biological systems at the molecular level with the tool set offered by modern chemistry

Tim Mitchison

Tim Mitchison

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Department

Sys Bio

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Systematic and quantitative methods to address problems in basic cell biology and medicine

Mark Namchuk

Mark Namchuk

Executive Director of Therapeutics Translation

Department

Therapeutics Initiative

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Identification and harnessing basic insights into clinical therapies

Kamila Naxerova

Kamila Naxerova

Assistant Professor, Radiology, Harvard Medical School
Principal Investigator, Center for Systems Biology, Massachusetts General Hospital

Department

CSB

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Interdisciplinary approaches to study the origins and consequences of somatic variation

Jin-Ah Park

Jin-Ah Park

Associate Professor of Airway Biology

Department

Enviromental Health

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The role of airway epithelium in the lung

Norbert Perrimon

Norbert Perrimon

Professor of Genetics, Blavatnik Institute, Harvard Medical School
Investigator, Howard Hughes Medical Institute

Department

Genetics

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Characterization of the mechanisms by which cells, tissues and organs communicate during development and in mature animals.

Deepak Rao

Deepak Rao

Assistant Professor of Medicine | Harvard Medical School
Division of Rheumatology, Inflammation, and Immunity
Co-Director, Human Immunology Center | Brigham and Women’s Hospital

Department

Medicine

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The use of high dimensional and mechanistic studies to define immunologic pathways that drive autoimmune diseases.

Lee Rubin

Lee Rubin

Professor of Stem Cell and Regenerative Biology
Co-director, Harvard Stem Cell Institute Nervous System Disease Program
Executive Committee Member
Harvard Stem Cell Institute

Department

Immunology

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Molecular mediators of various neurodegenerative diseases , to help develop preclinical therapeutics.

Eric Rubin

Eric Rubin

Adjunct Professor of Immunology and Infectious Diseases Professor of Medicine,
Medicine-Brigham and Women's Hospital,
Harvard Medical School

Department

SCRB

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i) Cell function (wall metabolism, cell growth and translation), ii) antibiotics study and development, iii) and tools development to study mycobacteria both in vitro and during infection.

Pardis Sabeti

Pardis Sabeti

Professor of Immunology and Infectious Diseases

Immunology and Infectious Diseases
Professor of Organismic and Evolutionary Biology

OEB Instruction + Org Res -Other Academic

Harvard Faculty of Arts and Sciences

Department

OEB

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i) Infectious diseases, ii) Functional analysis, iii) Computational biology

Chris Sander

Chris Sander

Professor in Residence of Cell Biology

Department

Biophysics

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Solving biological problems using quantitative methods from bioinformatics, machine learning, statistical physics, data science and mathematics

David Scadden

David Scadden

Gerald and Darlene Jordan Professor of Medicine

Department

SCRB

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The principles governing blood cell production to guide the development of therapies for blood disorders & cancer

Bill Sellers

Bill Sellers

Professor of Medicine

Department

Medicine

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Leveraging the link between genetic alterations and cancer dependencies to
elucidate new therapeutic hypotheses and develop novel therapeutics

Pamela Silver

Pamela Silver

Elliot T and Onie H Adams Professor of Biochemistry and Systems Biology

Department

Sys Bio

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Therapeutic design, cell programming, and environment and pathogen sensing

Peter Sorger

Peter Sorger

Otto Krayer Professor of Systems Pharmacology

Department

Sys Bio

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The systems biology of signal transduction networks controlling cell proliferation and death, the dysregulation of these networks in cancer and inflammatory diseases and the mechanisms of action of therapeutic drugs targeting signaling proteins

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