TGP Faculty
Judith Agudo
Assistant Professor of Immunology, Harvard Medical School
Department
Immunology
Research Area
Immunogenicity of stem cells
Dan Barouch
William Bosworth Castle Professor of Medicine, Harvard Medical School
Director, Center for Virology and Vaccine Research, BIDMC
Department
Virology
Research Area
Immunology and pathogenesis of viral infections and developing novel vaccine and treatment strategies.
Tom Bernhardt
Professor of Microbiology and Immunobiology, Harvard Medical School
Associate Director of Biological and Biomedical Sciences, Harvard Medical School
Department
Microbiology
Research Area
Molecular mechanisms of bacterial growth
Rameen Beroukhim
Associate Professor of Medicine
Department
Cancer Biology
Research Area
Investigations of the genetic changes that occur through cancer evolution and their affect on cancer behavior.
Stephen Blacklow
Gustavus Adolphus Pfeiffer Professor, Department of Biological Chemistry and Molecular Pharmacology (BCMP)
Chair of Department of BCMP, Harvard Medical School
Member of Department of Cancer Biology, Dana-Farber Cancer Institute
Department
BCMP
Research Area
Understand molecular mechanisms of signal transduction in normal and pathophysiologic contexts
Sara Buhrlage
Assistant Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Assistant Professor of Cancer Biology, Dana-Farber Cancer Institute
Department
BCMP
Research Area
Revolutionizing our ability to interrogate deubiquitinase (DUB) biology, validate DUBs as therapeutic targets, and develop small molecule-based ligands suitable for clinical development
Barbara Burleigh
Professor of Immunology and Infectious Diseases
Department
Immunology
Research Area
Studying of host fatty acid metabolism and its role in fueling T. cruzi replication in myoblasts and iPSC-derived human cardiomyocytes
Flaminia Catterucia
Professor at the Department of Immunology and Infectious Diseases in the Harvard T.H. Chan School of Public Health
Department
Immunology
Research Area
Molecular basis of reproductive biology in Anopheles mosquitoes
Constance Cepko
Bullard Professor of Genetics and Neuroscience at Harvard Medical School
Professor of Ophthalmology at Mass. Eye and Ear Infirmary
Department
Genetics
Research Area
The mechanisms that cells use when they choose their fate during development of the central nervous system
Edward Chouchani
Associate Professor of Cancer Biology (Dana-Farber Cancer Institute)
Associate Professor of Cell Biology (HMS)
Department
Cell Bio
Research Area
We apply mass spectrometry and biochemical approaches to understand how metabolites regulate cellular function in pre-clinical models of health and disease
George Church
Robert Winthrop Professor of Genetics, Harvard Medical School
Department
Genetics
Research Area
Transformative technologies for reading & writing 3D/4D structures at any scale
Karen Cichowski
Professor of Medicine, Harvard Medical School
Professor of Medicine/Genetics, Brigham And Women's Hospital
Department
Genetics
Research Area
How deregulated cell signaling drives cancer
Monica Colaiacovo
Professor of Genetics
Department
BCMP
Research Area
Mechanisms underlying germline maintenance and accurate chromosome inheritance during meiosis
Phil Cole
Professor of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Department
Genetics
Research Area
The chemical biology of protein post-translational modifications (PTMs) in the context of signaling, epigenetics, and cancer
Sloan Devlin
Assistant Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Associate Member of the Harvard Digestive Disease Center
Department
BCMP
Research Area
Leveraging expertise in organic chemistry, analytical chemistry, biochemistry, microbiology, cell biology, and gnotobiotic in vivo experiments to understand how human gut bacteria contribute to health and disease
Manoj Duraisingh
John LaPorte Given Professor of Immunology and Infectious Diseases
Department
Immunology
Research Area
The elucidation of the mechanism by which Plasmodium parasites invade host red blood cells (RBCs), within which they proliferate or become transmissible sexual forms
Michael Eck
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Professor of Cancer Biology, Dana-Farber Cancer Institute
Department
BCMP
Research Area
Using biochemical and biophysical methods (including X-ray crystallography and cryo electron microscopy) to distill problems of central importance in cancer biology to their structural and mechanistic essentials.
Eric Fischer
Assistant Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Independent Investigator of Cancer Biology, Dana-Farber Cancer Institute
Department
BCMP
Research Area
Combining structural biology, cell biology and chemical biology to address the molecular workings of these multi-component ubiquitin ligases.
Benjamin Gewurz
Associate Professor, Medicine, Harvard Medical School
Physician, Medicine/Infectious Disease, Brigham And Women's Hospital
Associate Chair, Virology Program, Harvard Medical School
Department
Medicine
Research Area
The gamma-herpesvirus Epstein Barr virus (EBV) as a master regulator of B-cell biology
David Golan
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
George R. Minot Professor of Medicine, Brigham and Women's Hospital
Dean for Research Operations and Global Programs, Research Operations and Global Programs, Harvard Medical School
Department
BCMP
Research Area
Smita Gopinath
Assistant Professor of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Department
Immunology
Research Area
The interactions between the commensal microbiota, pathogens and the host immune response in the one place they must necessarily meet – the mucosa
Chenghua Gu
Professor of Neurobiology, Harvard Medical School
Department
Neurobiology
Research Area
The cellular and physiological mechanisms underlying the unique neurovascular interactions including the blood-brain barrier and neurovascular coupling, and to harness our discoveries for therapeutics
James Gusella
Bullard Professor of Neurogenetics, Genetics, Harvard Medical School
Director, Center for Human Genetic Research, Massachusetts General Hospital
Department
Genetics
Research Area
Genetics of disease from gene discovery through pathogenesis, prediction and treatment
Stephen Haggarty
Associate Professor of Neurology, Harvard Medical School
Associate in Neuroscience, Massachusetts General Hospital
Director of Chemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital
Department
Chem Bio
Research Area
The cellular mechanisms underlying neuroplasticity and related pathways for the treatment of various neuropsychiatric and neurological disorders
Darren Higgins
Professor of Microbiology, Harvard Medical School
Department
Microbiology
Research Area
The molecular mechanisms of intracellular bacterial pathogenesis, host-pathogen interactions and the cellular immune response to intracellular pathogens
Cigall Kadoch
Assistant Professor of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School
Institute Member and Co-Director, Epigenomics Program, Broad Institute of Harvard and MI
Department
BCMP
Research Area
Chromatin Remodeling in Health and Disease
Randall King
Harry C. McKenzie Professor of Cell Biology, Harvard Medical School
Department
Cell Bio
Research Area
Understanding the Role of the Ubiquitin System During Cell Division
Andrew Kruse
Professor of Biological Chemistry and Molecular Pharmacology
Department
BCMP
Research Area
The molecular basis of membrane protein signaling using techniques including protein engineering, structural biology, and molecular pharmacology
Dan Kuritzkes
Harriet Ryan Albee Professor of Medicine
Department
Medicine
Research Area
Antiretroviral therapy and drug resistance in HIV-1 infection
David Liu
Thomas Dudley Cabot Professor of the Natural Sciences
Howard Hughes Medical Institute Investigator
Department
CCB
Research Area
Creatively integrating chemistry and evolution to illuminate biology and enable new therapeutics
Jeffrey Macklis
Max and Anne Wien Professor of Life Sciences
Professor of Stem Cell and Regenerative Biology, Harvard University
Professor of Neurology, Harvard Medical School
Director, Developmental and Regenerative Biology Ph.D. Program, Harvard University
Faculty Member, Harvard University Center for Brain Science
Executive Committee Member, Harvard Stem Cell Institute
Department
SCRB
Research Area
Neocortical projection neuron development and subtype specification in mice and human neuron models
Brendan Manning
Acting Chair and Professor of Molecular Metabolism, Department of Molecular Metabolism, Harvard. T.H. Chan School of Public Health
Affiliate Professor of Cell Biology, Harvard Medical School
Member of the Dana Farber/Harvard Cancer Cente
Department
Cell Bio
Research Area
Cell signaling and metabolism in cancer, metabolic diseases, and aging
Debbie Marks
Associate Professor of Systems Biology
Department
Sys Bio
Research Area
Building models to make sense of genetic variation and design biological tools for environmental and human health.
Jarrod Marto
Associate Professor, Pathology, Harvard Medical School
Associate Professor, Cancer Biology, Oncologic Pathology, Dana-Farber Cancer Institute
Department
Pathology
Research Area
Interrogating the functional proteome to understand how genomic alterations, environmental insults, or the action of small molecule chemical probes impact individual proteins
Marcela Maus
Associate Professor, Medicine, Harvard Medical School
Director of Cellular Immunotherapy, Cancer Center, Massachusetts General Hospita
Department
Medicine
Research Area
Designing and Evaluating next generation genetically-modified (CAR) T cells as immunotherapy in patients with cancer
Ralph Mazitschek
Assistant Professor at Harvard Medical School and Co-Director of the Chemical Biology Platform at the Center for Systems Biology at Massachusetts General Hospital (MGH)
Department
CSB
Research Area
The interface of biology and organic chemistry, and aims to study biological systems at the molecular level with the tool set offered by modern chemistry
Tim Mitchison
Hasib Sabbagh Professor of Systems Biology, Harvard Medical School
Department
Sys Bio
Research Area
Systematic and quantitative methods to address problems in basic cell biology and medicine
Mark Namchuk
Executive Director of Therapeutics Translation
Department
Therapeutics Initiative
Research Area
Identification and harnessing basic insights into clinical therapies
Kamila Naxerova
Assistant Professor, Radiology, Harvard Medical School
Principal Investigator, Center for Systems Biology, Massachusetts General Hospital
Department
CSB
Research Area
Interdisciplinary approaches to study the origins and consequences of somatic variation
Jin-Ah Park
Associate Professor of Airway Biology
Department
Enviromental Health
Research Area
The role of airway epithelium in the lung
Norbert Perrimon
Professor of Genetics, Blavatnik Institute, Harvard Medical School
Investigator, Howard Hughes Medical Institute
Department
Genetics
Research Area
Characterization of the mechanisms by which cells, tissues and organs communicate during development and in mature animals.
Deepak Rao
Assistant Professor of Medicine | Harvard Medical School
Division of Rheumatology, Inflammation, and Immunity
Co-Director, Human Immunology Center | Brigham and Women’s Hospital
Department
Medicine
Research Area
The use of high dimensional and mechanistic studies to define immunologic pathways that drive autoimmune diseases.
Lee Rubin
Professor of Stem Cell and Regenerative Biology
Co-director, Harvard Stem Cell Institute Nervous System Disease Program
Executive Committee Member
Harvard Stem Cell Institute
Department
Immunology
Research Area
Molecular mediators of various neurodegenerative diseases , to help develop preclinical therapeutics.
Eric Rubin
Adjunct Professor of Immunology and Infectious Diseases Professor of Medicine,
Medicine-Brigham and Women's Hospital,
Harvard Medical School
Department
SCRB
Research Area
i) Cell function (wall metabolism, cell growth and translation), ii) antibiotics study and development, iii) and tools development to study mycobacteria both in vitro and during infection.
Pardis Sabeti
Professor of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Professor of Organismic and Evolutionary Biology
OEB Instruction + Org Res -Other Academic
Harvard Faculty of Arts and Sciences
Department
OEB
Research Area
i) Infectious diseases, ii) Functional analysis, iii) Computational biology
Chris Sander
Professor in Residence of Cell Biology
Department
Biophysics
Research Area
Solving biological problems using quantitative methods from bioinformatics, machine learning, statistical physics, data science and mathematics
David Scadden
Gerald and Darlene Jordan Professor of Medicine
Department
SCRB
Research Area
The principles governing blood cell production to guide the development of therapies for blood disorders & cancer
Bill Sellers
Professor of Medicine
Department
Medicine
Research Area
Leveraging the link between genetic alterations and cancer dependencies to
elucidate new therapeutic hypotheses and develop novel therapeutics
Pamela Silver
Elliot T and Onie H Adams Professor of Biochemistry and Systems Biology
Department
Sys Bio
Research Area
Therapeutic design, cell programming, and environment and pathogen sensing
Peter Sorger
Otto Krayer Professor of Systems Pharmacology
Department
Sys Bio
Research Area
The systems biology of signal transduction networks controlling cell proliferation and death, the dysregulation of these networks in cancer and inflammatory diseases and the mechanisms of action of therapeutic drugs targeting signaling proteins